BPKDi

Names

[ CAS No. ]:
1201673-28-0

[ Name ]:
BPKDi

Biological Activity

[Description]:

BPKDi is a potent bipyridyl PKD inhibitor with IC50s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> PKD

[Target]

PKD1:1 nM (IC50)

PKD2:9 nM (IC50)

PKD3:1 nM (IC50)

[References]

[1]. Lauren Monovich, et al. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 2010 Feb 5;584(3):631-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈N₆O

[ Molecular Weight ]:
380.49

Related Compounds

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