Gadoteridol

Names

[ CAS No. ]:
120066-54-8

[ Name ]:
Gadoteridol

[Synonym ]:
prohance
Indole-3-carboxaldoxiMe
gadolinium-hp-do3a
gd-hp-do3a
Gd(III) 1-(4,7,10-triscarboxymethyl-(1,4,7,10-tetraazacyclododecyl))-2-methyl-ethoxy
Gadoteridol
2-(Acetoxy)thiobenzaMide
3-(Acetoxy)thiobenzaMide
Gd-10-(2-hydroxy-propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate

Biological Activity

[Description]:

Gadoteridol is a gadolinium-based MRI contrast agent, used in the imaging of the central nervous system.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
668.2ºC at 760 mmHg

[ Melting Point ]:
>225ºC

[ Molecular Formula ]:
C₁₇H₂₈GdN₄O₇

[ Molecular Weight ]:
557.67700

[ Flash Point ]:
357.9ºC

[ Exact Mass ]:
558.12000

[ PSA ]:
101.09000

[ Vapour Pressure ]:
1.04E-20mmHg at 25°C

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW4430000

CHEMICAL NAME :: Gadolinium, (10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane- 1,4,7-triacetato(3-)- N(sup 1),N(sup 4),N(sup 7),N(sup 10),O(sup 1),O(sup 4),O(sup 7),O(sup 10))-

CAS REGISTRY NUMBER :: 120066-54-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H29-Gd-N4-O7

MOLECULAR WEIGHT :: 558.75

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5587 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,187,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,187,1992

Safety Information

[ RIDADR ]:
NONH for all modes of transport