[D-Asp3]-Microcystin-LR

Names

[ CAS No. ]:
120011-66-7

[ Name ]:
[D-Asp3]-Microcystin-LR

[Synonym ]:
Toxin II,cyanobacterium
Cyclo-ala-leu-isoasp-arg-adda-isoglu-N-mdha

Biological Activity

[Description]:

Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. Microcystin-[D-Asp3]-LR/Microcystin A can activate Nrf2 and promote oxidative stress response. Microcystin-[D-Asp3]-LR/Microcystin A can also be used in toxicology research[1][2].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

[In Vitro]

Microcystin 的毒性主要靶向肠、肝、肾和生殖系统。其分子毒理学涉及蛋白磷酸酶的共价结合和抑制、氧化应激、细胞死亡（自噬、凋亡、坏死）和细胞骨架破坏[1]。 Microcystin-[D-Asp3]-LR/Microcystin A ([D-Asp3]-LR Microcystin) (1 μM) 显着增加 Nrf2 活性，从而表明氧化应激反应诱导[2]。

[References]

[1]. Arman T, et al. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins (Basel). 2021 Jul 29;13(8):537.

[2]. Lundqvist J, et al. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon. 2017 Feb;126:47-50.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Molecular Formula ]:
C₄₈H₇₂N₁₀O₁₂

[ Molecular Weight ]:
981.15

[ Exact Mass ]:
980.53300

[ PSA ]:
361.58000

[ LogP ]:
3.36630

[ Index of Refraction ]:
1.6

Related Compounds

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