1,2,4-Trichlorobenzene
Names
[ CAS No. ]:
120-82-1
[ Name ]:
1,2,4-Trichlorobenzene
[Synonym ]:
1,2,5-Trichlorobenzene
EINECS 204-428-0
1,4,5-trichlorobenzene
1,2,4-Trichlorbenzene
Benzene, 1,2,4-trichloro-
MFCD00000547
1,2,4-trichloro-benzene
Trojchlorobenzen
1,2,4-Trichlorobenzene
Hostetex l-pec
1,2,4-Trichlorbenzol
as-trichlorobenzene
1,2,4-Trichlorobenze
1,2,4-Trichlorobenzol
1,3,4-trichlorobenzene
1,2,4-trichlorobenzene—
Hipochem GM
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
211.4±20.0 °C at 760 mmHg
[ Melting Point ]:
16 °C(lit.)
[ Molecular Formula ]:
C6H3Cl3
[ Molecular Weight ]:
181.447
[ Flash Point ]:
126.7±0.0 °C
[ Exact Mass ]:
179.930038
[ LogP ]:
3.82
[ Vapour density ]:
>6 (vs air)
[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.567
[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Combustible.
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DC2100000
- CHEMICAL NAME :
- Benzene, 1,2,4-trichloro-
- CAS REGISTRY NUMBER :
- 120-82-1
- BEILSTEIN REFERENCE NO. :
- 0956819
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 31
- MOLECULAR FORMULA :
- C6-H3-Cl3
- MOLECULAR WEIGHT :
- 181.44
- WISWESSER LINE NOTATION :
- GR BG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 756 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6139 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1223 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg/14D-C
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7380 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1800 mg/kg
- SEX/DURATION :
- female 9-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 750 mg/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** REVIEWS *** ACGIH TLV-CL 37 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-BELGIUM:STEL 5 ppm (37 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (40 mg/m3);STEL 10 ppm (74 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (40 mg/m3);STEL 5 ppm (40 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,2,4-TRICHLOROBENZENE-air:CL 5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83334 No. of Facilities: 74 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 1687 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83334 No. of Facilities: 78 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 4033 (estimated) No. of Female Employees: 1463 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H410
[ Precautionary Statements ]:
P273-P501
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R38;R50/53
[ Safety Phrases ]:
S23-S37/39-S60-S61-S45-S36/37-S16
[ RIDADR ]:
UN 2321 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
DC2100000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
29036990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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