Dexloxiglumide

Names

[ CAS No. ]:
119817-90-2

[ Name ]:
Dexloxiglumide

[Synonym ]:
CR-2017
Dexloxiglumida [INN-Spanish]
Dexloxiglumidum [INN-Latin]
Dexloxiglumidum
Dexloxiglumida
Dexloxiglumide

Biological Activity

[Description]:

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9.

[2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

Chemical & Physical Properties

[ Density]:
1.233g/cm3

[ Boiling Point ]:
632.2ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₃₀Cl₂N₂O₅

[ Molecular Weight ]:
461.37900

[ Flash Point ]:
336.1ºC

[ Exact Mass ]:
460.15300

[ PSA ]:
95.94000

[ LogP ]:
4.40280

[ Vapour Pressure ]:
7.51E-17mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ Hazard Codes ]:
Xn,Xi

Related Compounds

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