BMS 814580 phosphate
Names
[ CAS No. ]:
1197420-12-4
[ Name ]:
BMS 814580 phosphate
Biological Activity
[Description]:
A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in chronic diet-induced obese models with excellent safety profile.
[References]
References 1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR)
Chemical & Physical Properties
[ Molecular Formula ]:
C24H20ClF2N2O7PS
[ Molecular Weight ]:
584.912