BMS 814580

Names

[ CAS No. ]:
1197420-11-3

[ Name ]:
BMS 814580

[Synonym ]:
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl]-
MFCD30829296
6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one

Biological Activity

[Description]:

A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in a chronic diet-induced obese model.

[References]

References 1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
691.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₁₉ClF₂N₂O₄S

[ Molecular Weight ]:
504.934

[ Flash Point ]:
372.3±34.3 °C

[ Exact Mass ]:
504.072205

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.660

Related Compounds

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