Taribavirin

Names

[ CAS No. ]:
119567-79-2

[ Name ]:
Taribavirin

[Synonym ]:
Ribamidine
1-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide
Prodrug of ribavirin
Icn 3142

Biological Activity

[Description]:

Taribavirin is an inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus[1].Taribavirin, is a ribavirin prodrug, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

Taribavirin (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 0 μM, 0.1 μM, 1 μM, 2 μM Incubation Time: 24 hours Result: Decreased MCF-7 cell growth.

[References]

[1]. Abd-Rabou AA, et al. Taribavirin and 5-Fluorouracil-Loaded Pegylated-Lipid Nanoparticle Synthesis, p38 Docking, and Antiproliferative Effects on MCF-7 Breast Cancer. Pharm Res. 2018 Feb 27;35(4):76.

[2]. Deming P, et al. Taribavirin in the treatment of hepatitis C. Expert Opin Investig Drugs. 2011 Oct;20(10):1435-43.

Chemical & Physical Properties

[ Density]:
2.08g/cm3

[ Boiling Point ]:
595.5ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₃N₅O₄

[ Molecular Weight ]:
243.22000

[ Flash Point ]:
313.9ºC

[ Exact Mass ]:
243.09700

[ PSA ]:
150.50000

[ Vapour Pressure ]:
5.01E-15mmHg at 25°C

[ Index of Refraction ]:
1.851

Related Compounds

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