AZD 8683
Names
[ CAS No. ]:
1194737-07-9
[ Name ]:
AZD 8683
Biological Activity
[Description]:
A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4; reverse airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways, shows potential for chronic obstructive pulmonary disease (COPD) management. COPD Phase 2 Discontinued
[References]
References 1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53. 2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174. View Related Products by Target mAChR COPD
Chemical & Physical Properties
[ Molecular Formula ]:
C28H36BrN3O3
[ Molecular Weight ]:
542.518
Related Compounds
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