GanoMycin I

Names

[ CAS No. ]:
1191255-15-8

[ Name ]:
GanoMycin I

Biological Activity

[Description]:

Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[References]

[1]. Tran PT, et, al. Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1. Phytomedicine. 2019 Mar 1;55:1-8.

[2]. Wang K, et, al. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem. 2018 Apr 26;61(8):3609-3625.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆O₄

[ Molecular Weight ]:
342.43

[ Exact Mass ]:
342.18300

[ PSA ]:
66.76000

[ LogP ]:
5.09500

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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