Fluorobexarotene

Names

[ CAS No. ]:
1190848-23-7

[ Name ]:
Fluorobexarotene

[Synonym ]:
Fluorobexarotene
Teijin compound 1

Biological Activity

[Description]:

Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RXRα:12 nM (Ki)

RXRα:43 nM (EC50)

[References]

[1]. Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct 8;52(19):5950-66.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇FO₂

[ Molecular Weight ]:
366.46800

[ Exact Mass ]:
366.20000

[ PSA ]:
37.30000

[ LogP ]:
6.24280

Related Compounds

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