Glimepiride sulfonamide

Names

[ CAS No. ]:
119018-29-0

[ Name ]:
Glimepiride sulfonamide

[Synonym ]:
3-Ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,5-dihydro-1H-pyrrole-1-carboxamide
SulfonamideofGlimepiride
1H-Pyrrole-1-carboxamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-
MFCD08460214
GliMepiride Related CoMpound B
EINECS 411-850-0
Glimepiride sulfonamide
3-Ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,5-dihydro-1H-pyrrol-1-carboxamid
4-[2-(3-ethyl-4-methyl-2-oxy-3-pyrrolinyl-1-methylamide)-ethyl]benzenesulfonamide

Biological Activity

[Description]:

Glimepiride sulfonamide is a intermediate, and can be used to synthesize Glimepiride (HY-B0104) (antidiabetic agent)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Parmar HS, et al. Study on gluco-regulatory potential of glimepiride sulfonamide using in silico, in vitro and in vivo approaches. Curr Pharm Des. 2014;20(32):5212-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
177-179?C

[ Molecular Formula ]:
C₁₆H₂₁N₃O₄S

[ Molecular Weight ]:
351.421

[ Exact Mass ]:
351.125275

[ PSA ]:
117.95000

[ LogP ]:
0.43

[ Index of Refraction ]:
1.588

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R52/53

[ Safety Phrases ]:
61

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Simultaneous determination of Glimepiride and Metformin hydrochloride impurities in sustained release pharmaceutical drug product by HPLC. Pawar, Shraddha, et al.

Der Pharma Chemica 2.4 , 157-168, (2010)