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Nilutamide-d6

Names

[ CAS No. ]:
1189477-66-4

[ Name ]:
Nilutamide-d6

[Synonym ]:
Nilutamide-d6
Nilandron-d6
Nilandrone-d6
Anandron-d6

Biological Activity

[Description]:

Nilutamide-d6 (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the research of metastatic prostatic carcinoma[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Androgen Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3(1):9-25.

[3]. Ask K, et al. Metabolism of nilutamide in rat lung. Biochem Pharmacol. 2006 Jan 12;71(3):377-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H4D6F3N3O4

[ Molecular Weight ]:
323.25800

[ Exact Mass ]:
323.10000

[ PSA ]:
98.72000

[ LogP ]:
2.67660

Related Compounds