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HTS07545

Names

[ CAS No. ]:
118666-03-8

[ Name ]:
HTS07545

Biological Activity

[Description]:

HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

IC50: 30 nM (SQOR)[1]


[References]

[1]. Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18N2O3

[ Molecular Weight ]:
358.39

Related Compounds