SD-1029

Names

[ Name ]:
SD-1029

[Synonym ]:
9-(3,4-Dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione dihydrobromide
1H-Xanthene-1,8(2H)-dione, 9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-, hydrobromide (1:2)

Biological Activity

[Description]:

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells; inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2; inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.

[References]

References 1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. 2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605. 3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. View Related Products by Target STAT

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₀Cl₂N₂O₃•₂HBr

[ Molecular Weight ]:
639.247

[ Exact Mass ]:
636.015686

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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