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crotmadine

Names

[ CAS No. ]:
118266-99-2

[ Name ]:
crotmadine

[Synonym ]:
(2E)-1-(5-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-8-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one, 1-(3,4-dihydro-5-hydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-(4-hydroxyphenyl)-, (2E)-
(2E)-1-(5-Hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-8-yl)-3-(4-hydroxyphenyl)-2-propen-1-one
crotmadine

Biological Activity

[Description]:

Isodorsmanin A is an anti-inflammatory agent. Isodorsmanin A suppresses the production of inflammatory mediators and proinflammatory cytokines. Isodorsmanin A inhibits the phosphorylation of JNK, MAPK[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[References]

[1]. Chung YC, et al. Isodorsmanin A Prevents Inflammatory Response in LPS-Stimulated Macrophages by Inhibiting the JNK and NF-κB Signaling Pathways. Curr Issues Mol Biol. 2023 Feb 13;45(2):1601-1612.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
549.9±50.0 °C at 760 mmHg

[ Melting Point ]:
239-240℃

[ Molecular Formula ]:
C20H20O4

[ Molecular Weight ]:
324.37

[ Flash Point ]:
198.7±23.6 °C

[ Exact Mass ]:
324.136169

[ PSA ]:
66.76000

[ LogP ]:
4.75

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.633

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds