N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid

Names

[ Name ]:
N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid

[Synonym ]:
5-Deazacyclotetrahydrofolate
n-(4-{[3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)propyl]amino}benzoyl)-l-glutamic acid
543U76
5-DACTHF

Biological Activity

[Description]:

5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Styles, V.L. Synthesis of the penta-glutamyl derivative of N-[4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)-propyl]amino]benzoyl]-L-glutamic acid (5-DACTHF). An acyclic analogue of tetrahydrofolic acid. 1990. Journal of Heterocyclic Chemistry, 27: 1809-1813.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₄N₆O₆

[ Molecular Weight ]:
432.43000

[ Exact Mass ]:
432.17600

[ PSA ]:
214.51000

[ LogP ]:
1.41430

Related Compounds

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