RU-302

Names

[ Name ]:
RU-302

Biological Activity

[Description]:

RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor

[Target]

TAM, Axl[1]

[References]

[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄F₃N₃O₂S

[ Molecular Weight ]:
475.53

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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