(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane

Names

[ Name ]:
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane

Biological Activity

[Description]:

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

[Target]

Alkaline phosphatase (ALP)[1]

[In Vitro]

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (10 μM) 通过增加碱性磷酸酶 (ALP) 活性水平显著促进 MSCs 成骨分化。与对照组相比，早期成骨细胞分化率为162.0±1.4[1]。

[References]

[1]. Xu X, et al. Isolation and chatacterization of homoisoflavonoids from Dracaena cochinchinensis and their osteogenic activities in mouse mesenchymal stem cells. J Pharm Biomed Anal. 2016 Sep 10;129:466-472.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆O₃

[ Molecular Weight ]:
256.29644

Related Compounds

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