4,4'-Methylenebis(2,6-di-tert-butylphenol)

Names

[ CAS No. ]:
118-82-1

[ Name ]:
4,4'-Methylenebis(2,6-di-tert-butylphenol)

[Synonym ]:
Bis(3,5-di-tert-butyl-4-hydroxyphenyl)methane
4,4'-Methylenebis[2,6-bis(2-methyl-2-propanyl)phenol]
4,4'-methanediylbis(2,6-di-tert-butylphenol)
MFCD00008822
Phenol, 4,4'-methylenebis[2,6-bis(1,1-dimethylethyl)-
Ethanox 702
3,3',5,5'-Tetra-tert-butyl-4,4'-dihydroxydiphenylmethane
Phenol, 4,4'-methylenebis[2,6-di-tert-butyl-
4,4'-Methylenebis(2,6-di-tert-butylphenol)
EINECS 204-279-1
2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]phenol

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
459.5±40.0 °C at 760 mmHg

[ Melting Point ]:
155-159 °C(lit.)

[ Molecular Formula ]:
C₂₉H₄₄O₂

[ Molecular Weight ]:
424.659

[ Flash Point ]:
178.1±21.9 °C

[ Exact Mass ]:
424.334137

[ PSA ]:
40.46000

[ LogP ]:
9.49

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.527

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL9650000

CHEMICAL NAME :: Phenol, 4,4'-methylenebis(2,6-bis(1,1-dimethylethyl)-

CAS REGISTRY NUMBER :: 118-82-1

BEILSTEIN REFERENCE NO. :: 1916919

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C29-H44-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2021 mg/kg/1W-C

TOXIC EFFECTS :: Liver - other changes Blood - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 56700 mg/kg/2Y-C

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from large intestine Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536073 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83032 No. of Facilities: 7725 (estimated) No. of Industries: 96 No. of Occupations: 64 No. of Employees: 120009 (estimated) No. of Female Employees: 20306 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
SL9650000

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...