Syringin

Names

[ CAS No. ]:
118-34-3

[ Name ]:
Syringin

[Synonym ]:
β-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2,6-dimethoxyphenyl
Sinapyl 4-O-β-D-glucopyranoside alcohol
4-[(1E)-3-Hydroxy-1-propen-1-yl]-2,6-dimethoxyphenyl β-D-glucopyranoside
4-[(1E)-3-Hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenyl β-D-glucopyranoside
β-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2,6-dimethoxyphenyl, (E)-
MFCD00016778
Eleutheroside B
Ligustrin
Syringin
LILACIN
4-[(1E)-3-Hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenyl-β-D-glucopyranoside
Sinapyl alcohol 4-O-glucoside
β-D-Glucopyranoside, 4-[(1E)-3-hydroxy-1-propenyl]-2,6-dimethoxyphenyl
4-(3-Hydroxypropenyl)-2,6-dimethoxyphenyl-D-glucoside
Methoxyconiferine
β-D-Glucopyranoside, 4-[(1E)-3-hydroxy-1-propen-1-yl]-2,6-dimethoxyphenyl

Biological Activity

[Description]:

Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Liu J, et al. Syringin prevents bone loss in ovariectomized mice via TRAF6 mediated inhibition of NF-κB and stimulation of PI3K/AKT. Phytomedicine. 2018 Mar 15;42:43-50.

[2]. Li F, et al. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy. Int J Mol Med. 2017 Jan;39(1):199-207.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
642.6±55.0 °C at 760 mmHg

[ Melting Point ]:
192°C

[ Molecular Formula ]:
C₁₇H₂₄O₉

[ Molecular Weight ]:
372.367

[ Flash Point ]:
342.4±31.5 °C

[ Exact Mass ]:
372.142029

[ PSA ]:
138.07000

[ LogP ]:
-1.94

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.623

[ Storage condition ]:
2-8°C

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].

Zhongguo Zhong Yao Za Zhi 36(6) , 706-8, (2011)

To develop a RP-HPLC-ELSD method for the simultaneous determination of five glycosides in Aidi injection.The separation was carried out at 35 degrees C on a Kromasil C18 column (4.6 mm x 250 mm, 5 mic...

Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.

J. Nat. Med. 65(3-4) , 417-23, (2011)

Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome o...

[Chemical constituents from Exochorda racemosa].

Zhongguo Zhong Yao Za Zhi 36(9) , 1198-201, (2011)

To study the chemical constituents of Exochorda racemosa.Compounds were isolated and purified by silica gel, Sephadex LH-20, MCI gel and RP-18 column chromatography, and their structures were determin...