N-Desmethyl levofloxacin

Names

[ Name ]:
N-Desmethyl levofloxacin

[Synonym ]:
UNII-88ZBA45NC8
Levofloxacin related compound A
Uing 4-255
des-methyl levofloxacin
N-Desmethyl levofloxacin
Levofloxacin Impurity 2

Biological Activity

[Description]:

Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.

Chemical & Physical Properties

[ Density]:
1.517g/cm3

[ Boiling Point ]:
600.714ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈FN₃O₄

[ Molecular Weight ]:
347.34100

[ Flash Point ]:
317.101ºC

[ Exact Mass ]:
347.12800

[ PSA ]:
83.80000

[ LogP ]:
1.59560

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.677

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Pharmacokinetics and pharmacodynamics of fluoroquinolones. Rodvold, Keith A., and Melinda Neuhauser.

Pharmacotherapy 21.10P2 , 233S-252S, (2001)

Related Compounds

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