Tauroursodeoxycholate dihydrate

Names

[ CAS No. ]:
117609-50-4

[ Name ]:
Tauroursodeoxycholate dihydrate

Biological Activity

[Description]:

Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Caspase
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK[1] Caspase-3, Caspase-12[2]


[References]

[1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.

[2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H49NO8S

[ Molecular Weight ]:
535.73

[ Storage condition ]:
2-8℃

Related Compounds