PF0346275

Names

[ Name ]:
PF0346275

[Synonym ]:
N-(3-Chloro-4-fluorobenzyl)-1-methyl-N-{[(1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl}-1H-imidazole-4-carboxamide dihydrochloride
1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM); demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg).

[References]

References 1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6. 2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640. View Related Products by Target Glycine Transporter (GlyT)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂ClFN₄O

[ Molecular Weight ]:
449.777

[ Exact Mass ]:
448.099976

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.