Sulfamethoxypyridazine-D3

Names

[ Name ]:
Sulfamethoxypyridazine-D3

[Synonym ]:
Benzenesulfonamide, 4-amino-N-[6-(methyl-d3-oxy)-3-pyridazinyl]-
4-Amino-N-{6-[(2H3)methyloxy]-3-pyridazinyl}benzenesulfonamide

Biological Activity

[Description]:

Sulfamethoxypyridazine-d3 is the deuterium-labeled Sulfamethoxypyridazine (HY-B1387)[1]. Sulfamethoxypyridazine (Kynex) a long-acting dulfonamide[2].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Boger W P, et al. Sulfamethoxypyridazine (Kynex) a New Long-Acting Sulfonamide[J]. Antibiotic Med., 1956, 3(6): 378-87.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
564.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₉D₃N₄O₃S

[ Molecular Weight ]:
283.32

[ Flash Point ]:
295.4±32.9 °C

[ Exact Mass ]:
283.081848

[ LogP ]:
0.32

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.647

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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