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3-Mercaptopropionic acid NHS ester

Names

[ CAS No. ]:
117235-10-6

[ Name ]:
3-Mercaptopropionic acid NHS ester

[Synonym ]:
3-Mercapropropanoyl-N-hydroxysuccinimide ester
1-(3-mercapto-1-oxopropoxy)-2,5-pyrrolidinedione

Biological Activity

[Description]:

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.40±0.1 g/cm3

[ Boiling Point ]:
318.4±44.0 °C

[ Molecular Formula ]:
C7H9NO4S

[ Molecular Weight ]:
203.21600

[ Exact Mass ]:
203.02500

[ PSA ]:
102.48000

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds