Sophora-iso-flavone A

Names

[ Name ]:
Sophora-iso-flavone A

[Synonym ]:
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-
Sophora-iso-flavone A
5,5',7-Trihydroxy-2',2'-dimethyl-2'H,4H-3,8'-bichromen-4-one

Biological Activity

[Description]:

Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Inflammation/Immunology

[References]

[1]. Lin Y, et, al. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorg Med Chem. 2017 Jul 15;25(14):3706-3713.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
611.2±55.0 °C at 760 mmHg

[ Melting Point ]:
235-237℃

[ Molecular Formula ]:
C₂₀H₁₆O₆

[ Molecular Weight ]:
352.34

[ Flash Point ]:
223.9±25.0 °C

[ Exact Mass ]:
352.094696

[ PSA ]:
100.13000

[ LogP ]:
5.33

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds

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