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Aranorosin

Names

[ CAS No. ]:
117184-53-9

[ Name ]:
Aranorosin

[Synonym ]:
2,4-Dodecadienamide,N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5.1.0.0(sup 3,5))octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl
2,4-Dodecadienamide,N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5.1.0.0(3,5))octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl
(6R)-N-((1'R,3'S,5'R,7'S)-5-Hydroxy-6'-oxodihydro-3H-4',8'-dioxaspiro[furan-2,2'-tricyclo[5.1.0.03,5]octan]-4-yl)-4,6-dimethyldodeca-2,4-dienamide

Biological Activity

[Description]:

Aranorosin, a potent antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. H W Fehlhaber, et al. Aranorosin, a novel antibiotic from Pseudoarachniotus roseus. II. Structure elucidation. J Antibiot (Tokyo). 1988 Dec;41(12):1785-94.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
650.4ºC at 760mmHg

[ Molecular Formula ]:
C23H33NO6

[ Molecular Weight ]:
419.51100

[ Flash Point ]:
347.2ºC

[ Exact Mass ]:
419.23100

[ PSA ]:
100.69000

[ LogP ]:
2.56610

[ Vapour Pressure ]:
1.14E-19mmHg at 25°C

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JR1550000
CHEMICAL NAME :
2,4-Dodecadienamide, N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5. 1.0.0(sup 3,5)) octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl-
CAS REGISTRY NUMBER :
117184-53-9
LAST UPDATED :
199312
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H33-N-O6
MOLECULAR WEIGHT :
419.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,1780,1988

Related Compounds

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