Aranorosin

Names

[ Name ]:
Aranorosin

[Synonym ]:
2,4-Dodecadienamide,N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5.1.0.0(sup 3,5))octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl
2,4-Dodecadienamide,N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5.1.0.0(3,5))octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl
(6R)-N-((1'R,3'S,5'R,7'S)-5-Hydroxy-6'-oxodihydro-3H-4',8'-dioxaspiro[furan-2,2'-tricyclo[5.1.0.03,5]octan]-4-yl)-4,6-dimethyldodeca-2,4-dienamide

Biological Activity

[Description]:

Aranorosin, a potent antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. H W Fehlhaber, et al. Aranorosin, a novel antibiotic from Pseudoarachniotus roseus. II. Structure elucidation. J Antibiot (Tokyo). 1988 Dec;41(12):1785-94.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
650.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₃₃NO₆

[ Molecular Weight ]:
419.51100

[ Flash Point ]:
347.2ºC

[ Exact Mass ]:
419.23100

[ PSA ]:
100.69000

[ LogP ]:
2.56610

[ Vapour Pressure ]:
1.14E-19mmHg at 25°C

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR1550000

CHEMICAL NAME :: 2,4-Dodecadienamide, N-(dihydro-5'-hydroxy-6-oxospiro(4,8-dioxatricyclo(5. 1.0.0(sup 3,5)) octane-2,2'(3'H)-furan)-4'-yl)-4,6-dimethyl-

CAS REGISTRY NUMBER :: 117184-53-9

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H33-N-O6

MOLECULAR WEIGHT :: 419.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,1780,1988