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Mycophenolate mofetil hydrochloride

Names

[ CAS No. ]:
116680-01-4

[ Name ]:
Mycophenolate mofetil hydrochloride

Biological Activity

[Description]:

Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

Human Endogenous Metabolite


[References]

[1]. Nakanishi, T., et al., Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10(1): p. 91-7.

[2]. Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36(7): p. 598-611.

[3]. Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol, 2012. 37(1): p. 48-54.

Chemical & Physical Properties

[ Density]:
1.222g/cm3

[ Boiling Point ]:
637.6ºC at 760mmHg

[ Molecular Formula ]:
C23H32ClNO7

[ Molecular Weight ]:
469.96

[ Flash Point ]:
339.4ºC

[ Exact Mass ]:
469.18700

[ PSA ]:
94.53000

[ LogP ]:
3.26390

[ Vapour Pressure ]:
7.51E-17mmHg at 25°C

[ Index of Refraction ]:
1.557

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds