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TG6-129

Names

[ CAS No. ]:
1164464-14-5

[ Name ]:
TG6-129

[Synonym ]:
2-Propenamide, N-[[[4-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl]phenyl]amino]thioxomethyl]-3-(4-fluorophenyl)-, (2E)-
(2E)-N-({4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}carbamothioyl)-3-(4-fluorophenyl)acrylamide
TG6-129

Biological Activity

[Description]:

TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[References]

[1]. Ganesh T, et al. Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS Med Chem Lett. 2013 Jul 11;4(7):616-621.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C20H18FN5O3S3

[ Molecular Weight ]:
491.582

[ Exact Mass ]:
491.055573

[ LogP ]:
4.17

[ Index of Refraction ]:
1.697

Related Compounds