SB-206606

Names

[ Name ]:
SB-206606

Biological Activity

[Description]:

SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Beta-3 adrenergic receptor

[In Vitro]

[3H]SB-206606 binding to membranes from Chinese hamster ovary K1 cells transfected with the rat β3-AR with a Kd value of 58 nM[1]. [3H]SB-206606 binding to brown adipose tissue where beta 1-, beta 2-, and beta 3-adrenergic receptor subtypes are known to coexist with a Kd value of 38 nM[1].

[References]

[1]. Muzzin P, et al. Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606. Mol Pharmacol. 1994 Aug;46(2):357-63. PMID: 8078497.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂ClNO₄

[ Molecular Weight ]:
363.84

Related Compounds

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