(Rac)-5-Keto Fluvastatin

Names

[ Name ]:
(Rac)-5-Keto Fluvastatin

[Synonym ]:
(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3-hydroxy-5-oxohept-6-enoic acid

Biological Activity

[Description]:

(Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC50 of 8 nM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

[References]

[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄FNO₄

[ Molecular Weight ]:
409.45000

[ Exact Mass ]:
409.16900

[ PSA ]:
79.53000

[ LogP ]:
4.83630

Related Compounds

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