Galanolactone

Names

[ Name ]:
Galanolactone

[Synonym ]:
Galanolactone
(3E)-3-{2-[(1R,2S,4aS,8aS)-5,5,8a-Trimethyloctahydro-1H-spiro[naphthalene-2,2'-oxiran]-1-yl]ethylidene}dihydro-2(3H)-furanone
2(3H)-Furanone, dihydro-3-[2-[(1R,2S,4aS,8aS)-octahydro-5,5,8a-trimethylspiro[naphthalene-2(1H),2'-oxiran]-1-yl]ethylidene]-, (3E)-

Biological Activity

[Description]:

Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC50 of 38.5 µg/ml[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Galanolactone (compound 3) shows antifungal activities with MIC of >25, >25, 25, 25, >25 µg/mL for CandidaalbicansAJ4409, Candida albicansNHL 4019, CandidaguilliermondiiPW44, CandidatropicalisPW3O, Candida utilis 1AM 4220, respectively[1].

[References]

[1]. Morita H, et al. Cytotoxic and antifungal diterpenes from the seeds of Alpinia galanga. Planta Med. 1988 Apr;54(2):117-20.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
459.6±28.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₀O₃

[ Molecular Weight ]:
318.45

[ Flash Point ]:
197.3±18.6 °C

[ Exact Mass ]:
318.219482

[ PSA ]:
38.83000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.