mephobarbital
Controlled Substances
Names
[ CAS No. ]:
115-38-8
[ Name ]:
mephobarbital
[Synonym ]:
EINECS 204-085-7
MFCD00270034
5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione
Mephobarbital
Chemical & Physical Properties
[ Density]:
1.211 g/cm3
[ Boiling Point ]:
395.9ºC at 760 mmHg
[ Melting Point ]:
176ºC
[ Molecular Formula ]:
C13H14N2O3
[ Molecular Weight ]:
246.26200
[ Flash Point ]:
193.2ºC
[ Exact Mass ]:
246.10000
[ PSA ]:
66.48000
[ LogP ]:
1.30930
[ Vapour Pressure ]:
5.62E-07mmHg at 25°C
[ Index of Refraction ]:
1.543
[ Storage condition ]:
Controlled Substance, -20?C Freezer
[ Water Solubility ]:
Practically insoluble in water, very slightly soluble in ethanol (96 per cent).
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CQ6650000
- CHEMICAL NAME :
- Barbituric acid, 5-ethyl-1-methyl-5-phenyl-
- CAS REGISTRY NUMBER :
- 115-38-8
- BEILSTEIN REFERENCE NO. :
- 0256144
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C13-H14-N2-O3
- MOLECULAR WEIGHT :
- 246.29
- WISWESSER LINE NOTATION :
- T6VMVNV FHJ D1 F2 FR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Behavioral - anticonvulsant
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 5,237,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HPPAAL Helvetica Physiologia et Pharmacologica Acta. (Basel, Switzerland) V.1-26, 1943-68. Discontinued. Volume(issue)/page/year: 19,241,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,851,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,851,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 3360 mg/kg
- SEX/DURATION :
- female 1-40 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,839,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84700 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84700 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
Missing Phrase - N15.00950417
[ Hazard Codes ]:
Xn,T,F
[ Risk Phrases ]:
22-39/23/24/25-23/24/25-11
[ Safety Phrases ]:
36/37/39-45-36/37-16-7
[ RIDADR ]:
UN 3249
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)