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Losartan Carboxaldehyde

Names

[ CAS No. ]:
114798-36-6

[ Name ]:
Losartan Carboxaldehyde

[Synonym ]:
1H-imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-imidazole-5-carbaldehyde
2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde
2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carbaldehyde
2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde
2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde
[3H]-EXP 3179
1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
EXP 3179
2-butyl-4-chloro-5-formyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole
Losartan Carboxaldehyde
2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde
2-Butyl-4-chloro-1-[[2 inverted exclamation mark-(1H-tetrazol-5-yl)[1,1 inverted exclamation mark-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
DUP 167

Biological Activity

[Description]:

EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Rossi GP. Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?. Hypertension. 2009;54(4):710-712.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
666.7±65.0 °C at 760 mmHg

[ Melting Point ]:
84-86 °C

[ Molecular Formula ]:
C22H21ClN6O

[ Molecular Weight ]:
420.895

[ Flash Point ]:
357.0±34.3 °C

[ Exact Mass ]:
420.146545

[ PSA ]:
89.35000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.681

Synthetic Route

Precursor & DownStream


Related Compounds

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