Bromindione

Names

[ Name ]:
Bromindione

[Synonym ]:
2-(4'-bromophenyl)indane-1,3-dione
Haldinone
Bromindionum [INN-Latin]
2-(4-Brom-phenyl)-indan-1,3-dion
p-Bromindione
2-(4-bromophenyl)-1H-indene-1,3(2H)-dione
p-Bromphenylindandione
2-<4-Brom-phenyl>indandion-(1,3)
2-(4-bromophenyl)indan-1,3-dione
2-p-Bromophenylindandione
BROMINDIONE
Halinone
Bromophenindione
Fluidane
2-(4-BROMOPHENYL)-1,3-INDANDIONE

Biological Activity

[Description]:

Bromindione is a potent, long-acting, inandione-derived, oral anticoagulant compound.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.569g/cm3

[ Boiling Point ]:
450.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₉BrO₂

[ Molecular Weight ]:
301.13500

[ Flash Point ]:
151.2ºC

[ Exact Mass ]:
299.97900

[ PSA ]:
34.14000

[ LogP ]:
3.61190

[ Vapour Pressure ]:
2.72E-08mmHg at 25°C

[ Index of Refraction ]:
1.659

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK5150000

CHEMICAL NAME :: 1,3-Indandione, 2-(p-bromophenyl)-

CAS REGISTRY NUMBER :: 1146-98-1

BEILSTEIN REFERENCE NO. :: 1878512

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H9-Br-O2

MOLECULAR WEIGHT :: 301.15

WISWESSER LINE NOTATION :: L56 BV DV CHJ CR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 214 ug/kg

TOXIC EFFECTS :: Blood - hemorrhage

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 9,372,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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