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Spiramine A

Names

[ CAS No. ]:
114531-28-1

[ Name ]:
Spiramine A

[Synonym ]:
(1R,2R,3S,5S,7R,8R,12R,13S,18R,21R)-12-Methyl-4-methylene-14,19-dioxa-17-azaheptacyclo[10.7.2.2.0.0.0.0]tricos-3-yl acetate
spiramine B
(1R,2R,3S,5S,7R,8R,12R,13R,18R,21R)-12-Methyl-4-methylene-14,19-dioxa-17-azaheptacyclo[10.7.2.2.0.0.0.0]tricos-3-yl acetate

Biological Activity

[Description]:

Spiramine A (Spiramine C acetate (ester)) is a diterpene alkaloid with antitumor and antimicrobial activity. Spiramine A inhibits PAF-induced rabbit platelet aggregation in a concentration-dependent manner, with an IC50 vallue of 6.7 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Li L, et al. Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. Eur J Pharmacol. 2002 Aug 2;449(1-2):23-8.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C24H33NO4

[ Molecular Weight ]:
399.523

[ Exact Mass ]:
399.240967

[ PSA ]:
48.00000

[ LogP ]:
3.51

[ Index of Refraction ]:
1.603

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds