POP-3MB

Names

[ CAS No. ]:
1144114-27-1

[ Name ]:
POP-3MB

Biological Activity

[Description]:

POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

IC50: 2.5 μM (ICMT)[1]


[References]

[1]. Majmudar JD et al. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 1;20(1):283-95.  

Chemical & Physical Properties

[ Molecular Formula ]:
C38H39NO4S

[ Molecular Weight ]:
605.79

Related Compounds