mTOR inhibitor-13

Names

[ Name ]:
mTOR inhibitor-13

Biological Activity

[Description]:

mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

mTOR:0.29 nM (IC50)

PI3Kα:119 nM (IC50)

[References]

[1]. Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₂N₆O₂S

[ Molecular Weight ]:
458.54

Related Compounds

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