AEEA-AEEA

Names

[ Name ]:
AEEA-AEEA

[Synonym ]:
17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid
AEEA-AEEA

Biological Activity

[Description]:

AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.202±0.06 g/cm3

[ Molecular Formula ]:
C₁₂H₂₄N₂O₇

[ Molecular Weight ]:
308.32800

[ Exact Mass ]:
308.15800

[ PSA ]:
129.34000

[ Water Solubility ]:
Freely soluble (999 g/L) (25 ºC)

AEEA-AEEA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds