BRD7552

Names

[ Name ]:
BRD7552

[Synonym ]:
α-D-Glucopyranoside, methyl, 2,3-bis(1,3-benzodioxol-5-ylcarbamate) 4-[[4-(ethoxycarbonyl)phenyl]carbamate]
Methyl 2,3-bis-O-(1,3-benzodioxol-5-ylcarbamoyl)-4-O-{[4-(ethoxycarbonyl)phenyl]carbamoyl}-α-D-glucopyranoside

Biological Activity

[Description]:

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.Target: PDX1 [1]in vitro: BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

[References]

[1]. Yuan Y, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol. 2013 Dec 19;20(12):1513-1522.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
757.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₃H₃₃N₃O₁₅

[ Molecular Weight ]:
711.626

[ Flash Point ]:
412.0±32.9 °C

[ Exact Mass ]:
711.191162

[ PSA ]:
216.90000

[ LogP ]:
7.01

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.654

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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