Epimagnolin B

Names

[ Name ]:
Epimagnolin B

[Synonym ]:
(1R,3aR,4S,6aR)-1-(3,5-Dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
1H,3H-Furo[3,4-c]furan, 1-(3,5-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1R,3aR,4S,6aR)-

Biological Activity

[Description]:

Epimagnolin B is a bisepoxylignan isolated from Magnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic effects[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Epimagnolin B exhibits antiallergic effects without affecting the viability of BMMCs[1].

[References]

[1]. Kim JY, et al. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorg Med Chem Lett. 2009 Feb 1;19(3):937-40.

[2]. Xing Zhang, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects. RSC Advances. July 2017;7(54):34236-34243.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
548.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₈O₇

[ Molecular Weight ]:
416.464

[ Flash Point ]:
220.9±30.0 °C

[ Exact Mass ]:
416.183502

[ LogP ]:
2.75

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
2-8℃

Related Compounds

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