Semduramicin

Semduramicin (UK-61689) is an orally active anticoccidial agent with an IC50 value of 30.0 ng/mL for E. tenella. Semduramicin reduces the lesions of E. aceroulina, E. brunetti and E. maxima. Semduramicin (20-30 mg/kg) is well tolerates in broilers and possesses broad spectrum anticoccidial activity. Semduramicin can be used in beef and poultry industry as coccidian inhibitor and growth promoter[1][2][3].

Research Areas >> Infection

Semduramicin (25 mg/L；48 h) 显著减少了堆型艾美耳球虫、布氏艾美耳球虫和巨型艾美耳球虫的病变[1]。 Semduramicin 显示出主要的革兰氏阳性抗菌谱[3]。 Semduramicin 的抗菌谱[3] Strain Lactobacillus acidophilus Lactobacillus spp. Streptococcus zooepidemicus Clostridium perfringens Bacteroides fragilis B.vulgatus MIC (µg/mL) 1.56 6.25 4.68 6.25-12.5 50 100

Semduramicin (25 mg/kg；口服，6-8 天) 显著改善了被球虫感染的十日龄肉鸡公鸡的体重增加、病变以及死亡率[1]。 Semduramicin (7.5-120 mg/kg；口服，6 天) 对十天大的白来亨鸡中的柔嫩艾美耳球虫有抑制作用[3]。 Animal Model: Ten-day-old broiler cockerels[1]. Dosage: 25 mg/kg. Administration: Oral gavage; 6-8 days. Result: Effectively controlled mortality, lesions, and weight gain depression that occurred. Animal Model: Ten-day-old White Leghorn chicks[3]. Dosage: 7.5, 15, 20, 30, 40, 60 and 120 mg/kg. Administration: Oral gavage; 6 days. Result: Significantly inhibited weight gain over 60 mg/kg and increased lesions below 20 mg/kg.

[1]. Logan NB, at al. Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests. Poult Sci. 1993 Nov;72(11):2058-63.  

[2]. Cao V, et al. Treatment of Lasalocid A, Salinomycin and Semduramicin as ionophore antibiotics in pharmaceutical wastewater by PAMAM-coated membranes[J]. Environmental Technology & Innovation, 2020, 20: 101103.

[3]. Ricketts A P, et al. Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia[J]. Poultry science, 1992, 71(1): 98-103.