angiopeptin

Names

[ Name ]:
angiopeptin

[Synonym ]:
L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-norvalyl-L-cysteinyl-
3-(2-Naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-norvalyl-L-cysteinyl-L-threoninamide

Biological Activity

[Description]:

Angiopeptin, a cyclic octapeptide analogue of somatostatin, markedly inhibits myointimal proliferation in response to endothelial cell injury. Angiopeptin is a potent and full agonists to inhibit adenylate cyclase or stimulate extracellular acidification through the sst2 or sst5 receptor. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 production[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

[In Vivo]

Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation[1]. Angiopeptin (20 μg/kg; per day) significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%[1]. Animal Model: Rat (model of myointimal proliferation)[1] Dosage: 20 and 50 μg/kg Administration: I.h. Result: Inhibited neointimal formation. Animal Model: New Zealand white rabbit (model of myointimal proliferation)[1] Dosage: 20 μg/kg Administration: Per day Result: Inhibited coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%.

[References]

[1]. Lundergan CF, et al. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J Am Coll Cardiol. 1991;17(6 Suppl B):132B-136B.

[2]. Alderton F, et al. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001;132(3):760-766.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1502.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅₄H₇₁N₁₁O₁₀S₂

[ Molecular Weight ]:
1098.339

[ Flash Point ]:
862.5±34.3 °C

[ Exact Mass ]:
1097.482666

[ LogP ]:
4.91

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.642

Related Compounds

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