Caspofungin-d4

Names

[ CAS No. ]:
1131958-73-0

[ Name ]:
Caspofungin-d4

Biological Activity

[Description]:

Caspofungin-d4 (MK-0991-d4; L-743872-d4) is a deuterium labeled Caspofungin (HY-17006A). Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan[1][2][3].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7.

[3]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803.

Chemical & Physical Properties

[ Melting Point ]:
>101°C (dec.)

[ Molecular Formula ]:
C₅₂H₈₄D₄N₁₀O₁₅

[ Molecular Weight ]:
1097.34

[ Appearance of Characters ]:
Solid | White to Pale Beige

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under inert atmosphere

[ Stability ]:
Hygroscopic

[ Water Solubility ]:
Methanol (Slightly, Sonicated), Water (Slightly, Heated)