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CAY10594

Names

[ CAS No. ]:
1130067-34-3

[ Name ]:
CAY10594

[Synonym ]:
2-Naphthalenecarboxamide, N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-naphthamide

Biological Activity

[Description]:

CAY10594 is a potent phospholipase D2 (PLD2) inhibitor both in vitro (IC50=140 nM) and in cells (IC50=110 nM)[1]. CAY10594 strongly inhibits the invasive migration of breast cancer cells in vitro and ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[References]

[1]. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

[2]. Lee SK, et al. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019 May 10;9(1):7242.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
756.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H28N4O2

[ Molecular Weight ]:
428.526

[ Flash Point ]:
411.4±32.9 °C

[ Exact Mass ]:
428.221222

[ PSA ]:
64.68000

[ LogP ]:
1.63

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
2-8°C

Related Compounds