Gramicidin S

Names

[ CAS No. ]:
113-73-5

[ Name ]:
Gramicidin S

[Synonym ]:
5H,22H-dipyrrolo[1,2-a:1',2'-p][1,4,7,10,13,16,19,22,25,28]decaazacyclotriacontine-5,22-dione, 12,29-bis(3-aminopropyl)-1,2,3,6,9,12,15,17a,18,19,20,23,26,29,32,34a-hexadecahydro-8,11,14,17,25,28,31,34-octahydroxy-15,32-bis(1-methylethyl)-9,26-bis(2-methylpropyl)-6,23-bis(phenylmethyl)-, (6R,7E,9S,10E,12S,13E,15S,16E,17aS,23R,24E,26S,27E,29S,30E,32S,33E,34aS)-
Gramicidin C
Cyclo(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl)
Gramacidine S [INN-French]
Gramicin S 1
Gramicidinum S [INN-Latin]
Gramicidina S [INN-Spanish]
gramicidin s
Gramicin S-A

Biological Activity

[Description]:

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Mogi T, et al. Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics. Cell Mol Life Sci. 2009 Dec;66(23):3821-6.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1394.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆₀H₉₂N₁₂O₁₀

[ Molecular Weight ]:
1141.447

[ Flash Point ]:
797.4±34.3 °C

[ Exact Mass ]:
1140.705933

[ PSA ]:
353.38000

[ LogP ]:
0.10

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.596

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.