Benzquinamide hydrochloride

Names

[ CAS No. ]:
113-69-9

[ Name ]:
Benzquinamide hydrochloride

[Synonym ]:
EINECS 204-033-3

Biological Activity

[Description]:

Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Ki: 1,365, 691, and 545 nM (α2A, α2B,α2C receptor)[1]

[References]

[1]. Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11178-11183.

[2]. Mazzanti R, et al. Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₃ClN₂O₅

[ Molecular Weight ]:
440.96

Related Compounds

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