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Sildenafil-d3

Names

[ CAS No. ]:
1126745-90-1

[ Name ]:
Sildenafil-d3

[Synonym ]:
7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[[4-(methyl-d)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
5-[2-ethoxy-5-[4-(trideuteriomethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[[4-(methyl-d)-1-piperazinyl]sulfonyl]phenyl]-1,4-dihydro-1-methyl-3-propyl-
5-(2-Ethoxy-5-{[4-(H)methylpiperazin-1-yl]sulfonyl}phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-(2-Ethoxy-5-{[4-(H)methyl-1-piperazinyl]sulfonyl}phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Biological Activity

[Description]:

Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[References]

[1]. Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7

[2]. [2].Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.

[3]. [3]. Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.

[4]. Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
672.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H27D3N6O4S

[ Molecular Weight ]:
477.595

[ Flash Point ]:
360.5±34.3 °C

[ Exact Mass ]:
477.223755

[ PSA ]:
121.80000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.665

Related Compounds