1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one

Names

[ Name ]:
1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one

[Synonym ]:
aristolactam FI
piperolactam-A
1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one
10-amino-4-hydroxy-3-methoxyphenanthrene-1-carboxylic acid lactam
Dibenz[cd,f]indol-4(5H)-one, 1-hydroxy-2-methoxy-
piperlactam A

Biological Activity

[Description]:

Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Leishmania

[In Vitro]

Piperolactam A 对杜氏利什曼原虫野生型、耐药和野外分离的无菌无鞭毛体细胞系具有抑制活性，IC50 值为 60 ± 9.6 μM (野生型)，分别为 121 ± 18 μM (抗 SSG)、109 ± 15 μM (抗 PMM) 和 87 ± 12 μM (野外分离株)[1]。

[References]

[1]. Bhattacharya P, et al. In Vitro susceptibilities of wild and drug resistant Leishmania donovani amastigotes to piperolactam A loaded hydroxypropyl-β-cyclodextrin nanoparticles. Acta Trop. 2016 Jun;158:97-106.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
457.0±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₁NO₃

[ Molecular Weight ]:
265.26

[ Flash Point ]:
230.2±26.8 °C

[ Exact Mass ]:
265.073883

[ PSA ]:
62.32000

[ LogP ]:
2.34

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.776

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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